Archives of Bioinformatics and Computational Biology

ABSTRACT

Infertility has been increased globally as a common health problem which affects 18% of couples at the reproductive stage [1]. Abnormalities in anatomical, physiological, genetic, endocrine, and immunological aspects of the therapeutic system can affect a woman’s fertility rate [2], while the major female infertility influencing factors include age, onset of puberty, developmental programming, diseases like endometriosis, polycystic ovarian syndrome (PCOS), environment, and lifestyle [3]. However, 10% of infertility cases still have unexplained reasons and remain undiagnosed [1,4].

KEYWORDS

1. Female infertility
2. Bioinformatics
3. Next-generation sequencing
4. Genome-wide association studies
5. Whole exome sequencing